Watch Closely (one)pentobarbital will minimize the level or result of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can lessen panobinostat degrees by ~70% and lead to procedure fai